C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 31/70 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61L 27/00 (2006.01) C07K 7/08 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C08B 37/00 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2086323
Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with "selectins", including GMP-140, ELAM-1, and lymphocyte homing receptor. The three regions include amino acids 19-34, 54-72, and 66-89, based on the numbers of the residues contained in the peptide, with residue 1 de- fined as the N terminus of the mature protein after cleavage of the sig- nal peptide. Fucosylated sialyated lactosamine structures that bind to GMP-140 have also been discovered. The structure is created by ex- pression of .alpha.(1,3) fucosyltransferases capable of modifying acceptors containing .alpha.(2,3) sialic acid-substituted lactosaminoglycans. Le x, Ga1.beta.1,4(Fuc.alpha.1,3)GIcNAc.beta.1-R (where R is a protein or other carbohy- drate structure) forms the core of this sialyated structure. The peptides and carbohydrate structures are useful as diagnostics and for clinical applications in the modulation or inhibition of coagulation processes or inflammatory processes.
Bereskin & Parr
The Board Of Regents Of The University Of Oklahoma
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