Enantiomerically pure .beta.-d-dioxolane nucleosides with...

A - Human Necessities – 61 – K

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A61K 31/52 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2147893

The invention is a method for the treatment of humans infected with HBV that includes administering an HBV treatment amount of an enatiomerically pure .beta.-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2 or H, and X is selected from the group consisting of alkyl, acyl, monophosphate, diphosphate, and triphosphate, or its pharmaceutically acceptable salt.

Procédé de traitement des malades atteints du virus de l'hépatite B. Il consiste à administrer une dose efficace d'un nucléoside de beta-D-dioxolanyl purine à pureté énantiomère de la formule (I), dans laquelle R représente OH, Cl, NH2 ou H; et X est sélectionné dans le groupe constitué d'alkyle, acyle, monophosphate, diphosphate, triphosphate, ou son sel pharmaceutiquement acceptable.

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