Electrostatic device and method for immunological detection

Details Electrostatic device and method for immunological detection Electrostatic device and method for immunological detection

G - Physics

01

N

G01N 33/543 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2338783

The invention concerns a device and a method for ultrasensitive detection comprising an electrically inert porous sheet sandwiched between two positively charged fine electrodes. The invention uses the capacity of the electrodes, resulting from their powerful electrostatic properties, for sensing marked antibody complexes related to antigens detected in the sample, and to leave marked antibodies non-complexed with said antigens free. The method consists in depositing a sample droplet on the porous material sheet upstream of the electrodes and in detecting downstream of the electrodes, in a signal-zone, the possible presence of an antigen-antibody complex which has diffused in the porous material. The invention is useful for detecting some millipicogrammes of antigen per millilitre of sample.

L'invention concerne un dispositif et procédé de détection ultrasensible comprenant une feuille poreuse électriquement inerte prise en sandwich entre deux électrodes fines chargées positivement. L'invention met à profit la capacité des électrodes à capter, grâce à leur électrostatisme puissant, les complexes anticorps marqués liés aux antigènes détectés dans l'échantillon, et de laisser libres les anticorps marqués non complexés aux dits antigènes. On dépose une gouttelette d'échantillon sur la feuille de matière poreuse à l'amont des électrodes et on détecte à l'aval des électrodes, dans une zone- signal, l'éventuelle présence d'un complexe antigène-anticorps ayant diffusé dans la matière poreuse. L'invention est applicable à la détection de quelques millipicogrammes d'antigène par millilitre d'échantillon.

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