Process for the direct preparation of 5-alkoxy and 5-acyloxy...

Details Process for the direct preparation of 5-alkoxy and 5-acyloxy... Process for the direct preparation of 5-alkoxy and 5-acyloxy...

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01) C07D 491/14 (2006.01)

Patent

CA 2510177

A convenient and efficient process for direct preparation of 5-alkoxy and 5- acyloxy analogues of camptothecins (anticancer compounds) and mappicine ketones (antiviral compounds) has been invented by treatment of the parent compounds with alcohols and acids respectively in the presence of ceric ammonium nitrate (CAN) at room temperature. The process is simple, economic and completed within a short period of time.

L'invention concerne un procédé pratique et efficace de préparation directe d'analogues de 5-alcoxy et de 5-acyloxy de camptothécines (composés anticancéreux) et de mappicines cétones (composés antiviraux) par traitement des composés d'origine à l'aide d'alcools et d'acides respectivement, en présence de cérinitrate d'ammonium (CAN) à température ambiante. Ledit procédé est simple, économique et mis en oeuvre en peu de temps.

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