C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C12N 5/071 (2010.01) C12N 15/113 (2010.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2561221
The instant application relates to methods and reagent for modulating the Hedgehog signaling pathway using RNA interference technology (RNAi). The application provides potential targets of the Hedgehog RNAi, methods to identify additional Hedgehog signaling pathway components, methods to inhibit Hedgehog signaling targets using siRNA, and their uses in the treatment of a number of disease conditions.
La présente demande concerne des méthodes et des réactifs de modulation de la voie de signalisation Hedgehog (hérisson) utilisant la technologie d'interférence d'ARN (ARNi). Cette demande présente des cibles potentielles de ARNi Hedgehog, des méthodes d'identification de composantes supplémentaires de la voie de signalisation Hedgehog, des méthodes d'inhibition des cibles de signalisation Hedgehog au moyen d'un petit ARN interférent, et leur utilisation dans le traitement d'un certain nombre d'états pathologiques.
Borden Ladner Gervais Llp
Curis Inc.
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