A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 2/16 (2006.01) A61L 12/12 (2006.01) A61L 27/28 (2006.01) A61L 29/08 (2006.01) A61L 31/08 (2006.01) G02C 7/04 (2006.01)
Patent
CA 2594836
A compound of formula I: wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and preferably 10 to 20, is used to prevent biofilm formation on a surface. The compounds are particularly useful as coatings or treatments for medical devices, including stents, catheters and wire guides.
Un composé de formule I : où R1 représente un groupement alkyle linéaire ou ramifié en C8-C16 en position 2 ou 3 du cycle morpholine, et R2 représente un groupement alkyle linéaire ou ramifié en C2-C10, substitué par un groupement hydroxy sauf en position alpha, le nombre total d'atomes de carbone des groupements R1 et R2 étant d~au moins 10, et préférentiellement compris entre 10 et 20, est employé dans la prévention de la formation d'une pellicule biologique sur une surface. Les composés selon l'invention peuvent en particulier être employés en tant que revêtements ou traitements pour appareillages médicaux, y compris les armatures, les cathéters et les guides de tubes.
Lane Jonathan
Sjoedin Olof Torgny
Cassan Maclean
Sinclair Pharmaceuticals Limited
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