Recombinant iron uptake proteins

Details Recombinant iron uptake proteins Recombinant iron uptake proteins

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) A61K 39/095 (2006.01) C07K 1/22 (2006.01) C07K 14/22 (2006.01) C12N 1/21 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2403984

Neisserial iron uptake proteins including transferrin binding protein A (TbpA) and B (TbpB) in both full length form and as immunogenic fragments are made recombinantly. A non-neisserial cell expresses a TbpA which is extracted from the cell under mild conditions and retains substantially the antigenicity of native TbpA on its surface. TbpB is also made recombinantly and both TbpA and TbpB are included in vaccine compositions.

L'invention concerne des protéines de fixation du fer de Neisseria comprenant une protéine A de fixation de la transferrine (TbpA) et B (TbpB) pleine longueur et comme fragments immunogènes, fabriquées par recombinaison. Une cellules n'appartenant pas au genre Neisseria exprime une TbpA extraite de la cellule dans des conditions douces et retient sensiblement l'antigénicité des TbpA endogènes sur sa surface. La protéine TbpB est également obtenue par recombinaison et les protéines TbpA et TbpB sont utilisées dans des compositions de vaccins.

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