Therapeutic targeting of escort proteins

Details Therapeutic targeting of escort proteins Therapeutic targeting of escort proteins

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 31/12 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2668773

The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

La présente invention concerne l'inhibition de maladie virale par l'administration à un hôte de type mammifère d'anticorps dirigés contre une protéine d'escorte telle que la Tsg101. Ces protéines apparaissent sur la surface d'une cellule, et peuvent ainsi se lier à des anticorps en circulation. En liant les protéines d'escorte sur la surface cellulaire, le bourgeonnement de particules virales est inhibé. Le virus infecte les cellules initiales, mais ne peut pas s'échapper de la cellule pour infecter le corps en masse.

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