Use of pramipexole to treat amyotrophic lateral sclerosis

Details Use of pramipexole to treat amyotrophic lateral sclerosis Use of pramipexole to treat amyotrophic lateral sclerosis

A - Human Necessities

61

K

A61K 31/425 (2006.01) A61K 31/428 (2006.01)

Patent

CA 2468747

The present invention is directed to compositions comprising pramipexole and the use of such compositions to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in Fig. 6B the mean +1- SEM serum 2,3-DHBA levels for the 12 ALS participants decreased signifacantly after pramipexole treatment.

L'invention concerne des compositions comprenant du pramipexole, ainsi que l'utilisation de telles compositions pour traiter des maladies neurodégénératives telles que la sclérose latérale amyotrophique (ALS). Comme il est montré dans la figure 6B, les niveaux moyens de +1-SEM sérum 2,3-DHBA pour les 12 participants atteints d'ASL ont diminués significativement après un traitement au pramipexole.

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