G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) A61P 29/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2433348
The present invention relates to compositions and methods for identification and development of compounds or therapeutic agents that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to methods for detecting compounds or therapeutic agents that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in cells. The present invention provides compositions for and methods of treatment of biological conditions including, but not limited to, vascular complications of type I and type II diabetic induced vasculopathies, other vasculopathies, microangiopathies, renal insufficiency, Alzheimer's syndrome, and inflammation- induced diseases such as atherosclerosis.
La présente invention concerne des compositions et des méthodes d'identification et de mise au point de composés ou d'agents thérapeutiques de traitement d'états pathophysiologiques générés par des réponses inflammatoires. La présente invention concerne, en particulier, des méthodes de détection de composés ou d'agents thérapeutiques inhibant ou bloquant l'induction produite par des protéines glyquées de réponses inflammatoires associées à la signalisation dans les cellules. La présente invention concerne des compositions et des méthodes de traitement d'états biologiques comprenant, entre autres, les complications vasculaires des vasculopathies induites par le diabète de type I et de type II, d'autres vasculopathies, des microangiopathies, l'insuffisance rénale, le syndrome d'Alzheimer, et les maladies induites par une inflammation telles que l'athérosclérose.
Cahoon Shianlen
Pillarisetti Sivaram
Saxena Uday
Finlayson & Singlehurst
Reddy Us Therapeutics Inc.
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