A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) A61K 31/663 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2497182
A pharmaceutical composition for treatment of malignancies, in particular multiple myeloma (MM), comprises in combination a bisphosphonate, e.g. zoledronic acid or a salt or ester, and an HMG-CoA reductase inhibitor for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an HMG-CoA reductase inhibitor.
L'invention concerne une composition pharmaceutique pour traiter des tumeurs malignes, notamment des myélomes multiples (MM). Cette composition comprend une combinaison de bisphosphonate, à savoir un acide zolédronique, un sel ou un ester, et d'un inhibiteur de réductase HMG-CoA pour une utilisation simultanée, séquentielle ou séparée. La présente invention porte également sur une méthode pour traiter un patient souffrant d'une maladie tumorale, laquelle méthode consiste à administrer au patient une quantité efficace d'un bisphosphonate et une quantité efficace d'un inhibiteur de réductase HMG-CoA.
Baulch-Brown Cindy Maree
Spencer Andrew
Fetherstonhaugh & Co.
Novartis Ag
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