Medicaments based on progestins for dermal use

Details Medicaments based on progestins for dermal use Medicaments based on progestins for dermal use

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 8/63 (2006.01) A61K 8/67 (2006.01) A61K 9/06 (2006.01) A61K 31/375 (2006.01) A61K 31/56 (2006.01) A61K 31/569 (2006.01) A61K 31/57 (2006.01) A61K 47/22 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2422974

The present invention relates to semisolid transcutaneous medicaments based on at least one oxidation-sensitive progestin or a pharmaceutically acceptable derivative thereof. The medicaments comprise ascorbic acid, an ascorbic acid derivative or a salt thereof and have excellent stability. Corresponding gets which comprise a combination of norethisterone acetate and estradiol are described in particular.

La présente invention concerne des médicaments transcutanés semi-solides à base d'au moins une progestine sensible à l'oxydation ou un dérivé pharmaceutiquement acceptable de ladite progestine. Lesdits médicaments comprennent de l'acide ascorbique, un dérivé de l'acide ascorbique ou un sel de ces substances et présentent une excellente stabilité. La présente invention concerne également et plus particulièrement des gels correspondants qui comprennent de l'acétate de noréthistérone en association avec de l'ostradiol.

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