Solid pharmaceutical composition comprising telithromycin

Details Solid pharmaceutical composition comprising telithromycin Solid pharmaceutical composition comprising telithromycin

A - Human Necessities

61

K

A61K 31/704 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2598210

The invention relates to a solid pharmaceutical composition comprising telithromycin or one of the addition salts thereof with a pharmaceutically-acceptable acid as an active principle. The invention is characterised in that the composition comprises the following components in relation to the total weight of the composition: between 0.1 and 80 wt.- % telithromycin or one of the addition salts thereof with a pharmaceutically-acceptable acid, and between 10 and 50 wt.- % of at least one diluent with a plastic behaviour. Advantageously, the invention takes the form of a telithromycin tablet having a noticeably-reduced size but providing an identical dosage of telithromycin and displaying improved mechanical properties.

L'invention a pour objet une composition pharmaceutique solide comprenant de la télithromycine ou un de ses sels d'addition avec un acide pharmaceutiquement acceptable, en tant que principe actif, caractérisée en ce qu'elle comprend, par rapport au poids total de la composition : de la télithromycine ou un de ses sels d'addition avec un acide pharmaceutiquement acceptable, selon une proportion en télithromycine comprise entre 0,1 et 80 % en poids, et au moins un agent diluant à comportement plastique, selon une proportion de 10 à 50 % en poids. Elle fournit avantageusement un comprimé de télithromycine ayant une taille sensiblement réduite, à dosage pourtant égal en télithromycine, et présentant des propriétés mécaniques améliorées.

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