A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/12 (2006.01) A61K 9/127 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2312767
The present invention relates to a drug delivery system with two-step targeting, which comprises a combination: (a) a lipid carrier provided with cell targeting agent(s) to target the drug delivery system to specific cells or tissues; and (b) a drug enclosed in said lipid carrier and provided with a DNA targeting agent to target the drug to the nuclei of specific target cells. Furthermore, the invention relates to a method of cancer therapy in which the above drug delivery system is administered to a cancer patient. The goal is to treat or analyse both large tumour masses as well as small tumour cell clusters and single spread tumour cells. According to the invention, drug uptake in tumours will be markedly increased at the same time as the interaction of the drug with healthy organs and tissues can be minimized. The invention gives potential to convert palliative into curative treatment.
L'invention concerne un système d'administration d'un médicament avec ciblage en deux temps comprenant une association a) d'un excipient lipide pourvu d'agent(s) de ciblage de cellule permettant de diriger le système d'administration de médicament vers des cellules ou tissus spécifiques; et b) d'un médicament enfermé dans ledit excipient lipide et pourvu d'un agent de ciblage d'ADN pour diriger le médicament vers le noyau des cellules cibles spécifiques. L'invention concerne également un procédé de traitement du cancer selon lequel le système d'administration de médicament est administré à un patient en vue de traiter ou d'analyser aussi bien de grandes quantités tumorales que des amas de petites cellules tumorales et des cellules tumorales individuelles dispersées. Selon l'invention, l'absorption du médicament par les tumeurs est considérablement augmentée, ce qui permet de réduire parallèlement l'interaction du médicament et des organes et tissus sains. L'invention donne l'opportunité de transformer un traitement palliatif en traitement curatif.
Carlsson Jorgen
Edwards Katarina
Sjoberg Stefan
Carlsson Jorgen
Cassan Maclean
Edwards Katarina
Nuclisome Ab
Sjoberg Stefan
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