C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/40 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/535 (2006.01) A61P 25/16 (2006.01) C07D 271/07 (2006.01) C07D 273/04 (2006.01) C07D 295/13 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2404128
A propenecarboxylic acid amidoxime derivative of the formula (see above formula) wherein R, R', R1, R2, R3, R4 and R5 are as defined in claim 1, or N-oxides and/or isomers and/or pharmaceutically suitable acid addition salts thereof. These compounds are for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on PARP inhibition and/or a viral disease and/or a disease caused by a toxic effect.
L'invention concerne de nouveaux dérivés amidoxime d'acide propènecarboxylique, des N-oxydes et/ou des isomères géométriques et/ou des isomères optiques et/ou des sels d'addition acides pharmaceutiquement acceptables et/ou des dérivés quaternaires de ces dérivés. Ces nouveaux composés sont utiles dans le traitement d'un état associé à un déficit en oxygène et/ou à un déficit énergétique, ou d'une maladie basée sur l'inhibition de la PARP, plus particulièrement une maladie auto-immune ou neurodégénerative et/ou une maladie virale et/ou une maladie induite par un effet toxique.
Literati Nagy Peter
Sumegi Balazs
Takacs Kalman
N-Gene Research Laboratories Inc.
Robic
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