C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01)
Patent
CA 2604933
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
Procédés et compositions destinés à être utilisés pour moduler la (les) activité(s) du polypeptide WISP-1. Des antagonistes de WISP-1 comprennent des anticorps anti-WISP-1, des immunoadhésines WISP-1 et des variants WISP-1 (et des protéines de fusion de ces substances) qui inhibent ou neutralisent l'induction ou la sécrétion de HAS2, HA, CD44 or RHAMM par un polypeptide WISP-1 humain natif dans au moins un type de cellule de mammifère. La présente invention concerne également des procédés de diagnostic in vitro, in situ et / ou in vivo et / ou de traitement de cellules de mammifères ou d'états pathologiques associés à des polypeptides WISP-1 natifs.
Desnoyers Luc
Filvaroff Ellen
Genentech Inc.
Smart & Biggar
LandOfFree
Methods and compositions for modulating and detecting wisp... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for modulating and detecting wisp..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for modulating and detecting wisp... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1483423