G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01)
Patent
CA 2731247
The present invention provides a method for predicting the short-term and long- term cognitive decline in Alzheimer's disease patients and uses thereof in predicting efficacy of an AD therapeutic. The method uses baseline levels of CSF biomarkers to predict decreases over time in CAMCOG and MMSE scores.
L'invention concerne un procédé pour prédire le déclin cognitif à court terme et long terme chez des patients souffrant de la maladie d'Alzheimer, et des utilisations de ceux-ci pour prévoir une efficacité d'une thérapie AD. Le procédé utilise des niveaux de ligne de base de biomarqueurs de CSF pour prévoir des diminutions au cours du temps des scores de CAMCOG et d'un mini-examen de l'état mental (MMSE).
Holder Daniel J.
Oulhaj Abderrahim
Seeburger Jeffrey L.
Smith David A.
Isis Innovation
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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