C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/00 (2006.01) A61F 9/00 (2006.01) A61K 9/00 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2446864
The present invention provides compounds of formula I:wherein A is N or CR, and G, R1, R2, and R3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des composés représentés par la formule (I) dans laquelle A est N ou CR, et G, R¿1?, R¿2?, et R¿3? Sont comme spécifiés dans le descriptif. Ces composés sont des inhibiteurs de protéine kinase, en particulier de protéine kinase Src de mammifère intervenant dans la prolifération des cellules, la mort cellulaire et la réponse à des stimuli extracellulaires. L'invention concerne également des procédés de fabrication de ces inhibiteurs. L'invention concerne également des compositions pharmaceutiques renfermant ces inhibiteurs et des méthodes qui font appel à ces compositions pour le traitement et la prévention de divers troubles.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
Inhibitors of src and other protein kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of src and other protein kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of src and other protein kinases will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1483927