Imidazole derivatives and their salts

Details Imidazole derivatives and their salts Imidazole derivatives and their salts

C - Chemistry, Metallurgy

07

D

260/305, 260/315

C07D 405/06 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/485 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07C 17/16 (2006.01) C07D 233/56 (2006.01) C07D 233/84 (2006.01) C07D 319/20 (2006.01)

Patent

CA 1111433

ABSTRACT OF THE INVENTION Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical formulations The invention relates to 1-arylalkylimidazoles of formula Image in which A is a straight or branched alkylene group of from 1 to 3 carbon atoms, or a straight or branched alkenylene or alkynylene group of 2 or 3 carbon atoms, n is an integer which is at least 1, and the or each R substituent, which when n is greater than 1 may be the same or different, is a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated, R may also be alkoxy of from 1 to 4 carbon atoms; (when n is at least 2) alkylenedioxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkoxy; carboaryloxy; carboarylalkyloxy; -NR6R7 or -CCNR6R7, in which R6 and R7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; or an acid addition salt of such a 1-arylalkylimidazole. Methods of preparing these 1-arylalkylimidazoles are disclosed. The 1-arylalkylimidazoles have pharmacological properties of use in medicine, in particular for the treatment or prophylaxis of thrombo-embolic disorders.

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