Method for obtaining vaccines for preventing the pathogenic...

A - Human Necessities – 61 – K

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A61K 39/21 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 15/48 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2309676

The invention concerns a method for obtaining a vaccine against the pathogenic effects related to infection of a host by a retrovirus, in the event that the target cells of the retrovirus have a membrane receptor for a protein of the host and the viral infection induces an immune response directed both against an envelope protein of the virus and against a protein of the host. The method consists in preparing a vaccine agent based on a polypeptide comprising a fragment of an immunodominant and preserved zone of the retrovirus envelope protein, in a modified form such that the vaccine agent induces an immune response directed against the envelope protein and not against the host protein.

Pour obtenir un vaccin contre les effets pathogènes associés à l'infection d'un hôte par un rétrovirus, dans le cas où les cellules cibles du rétrovirus possèdent un récepteur membranaire pour une protéine de l'hôte et où l'infection virale induit une réponse immunitaire dirigée à la fois contre une protéine d'enveloppe du virus et contre une protéine de l'hôte, on prépare un agent vaccinal à base d'un polypeptide comprenant un fragment d'une zone immunodominante et conservée de la protéine d'enveloppe du rétrovirus, sous une forme modifiée telle que l'agent vaccinal induit une réponse immunitaire dirigée contre la protéine d'enveloppe et non contre la protéine de l'hôte.

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