Human tumor necrosis factor receptor tr9

Details Human tumor necrosis factor receptor tr9 Human tumor necrosis factor receptor tr9

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) C07K 14/47 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2295991

The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

La présente invention concerne un nouveau membre de la famille des récepteurs du facteur de nécrose tumorale. Elle concerne en particulier des molécules d'acide nucléique codant le récepteur humain TR9. Elle concerne en outre des polypeptides TR9 ainsi que des vecteurs, des cellules hôtes, et des méthodes recombinantes permettant de produire lesdits polypeptides. L'invention concerne enfin des méthodes de sélection permettant d'identifier des agonistes et des antagonistes de l'activité du récepteur TR9.

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