Transduction of dendritic cells using adenoviral vectors

C - Chemistry – Metallurgy – 12 – N

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C12N 15/861 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2421864

Adenoviral vectors can be used in vaccines to cause antigen-presenting cells to display desired antigens. Disclosed is a vector and associated means and methods which transduce antigen-presenting cells better than currently available vectors, enabling the vector to be delivered in lower doses, and thus improving the efficiency of adenoviral vaccines technology.

Selon l'invention, des vecteurs adénoviraux peuvent être utilisés dans des vaccins pour amener des cellules présentatrices d'antigènes à présenter des antigènes désirés. On décrit un vecteur ainsi qu'un moyen et des méthodes associés qui accomplissent la transduction de cellules présentatrices d'antigènes mieux que des vecteurs actuellement disponibles, ce qui permet de transférer le vecteur à faibles doses, et donc d'améliorer l'efficience de la technologie des vaccins adénoviraux.

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