Treatment of b cell malignancies using combination of b cell...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2415100

A combination antibody therapy for treating B cell malignancies using an immunoregulatory antibody, especially an anti-B7, anti-CD23, or anti-CD40L antibody and a B cell depleting antibody, especially anti-CD19, anti-CD20, anti-CD22 or anti-CD37 antibody is provided. Preferably, the combination therapy will comprise anti-B7 and anti-CD20 antibody administration.

L'invention concerne une thérapie combinée d'anticorps destinée au traitement de malignités des cellules B au moyen d'un anticorps immunorégulateur, notamment un anticorps anti-B7, anti-CD23, ou anti-CD40L et d'un anticorps à action déplétive sur les cellules B, notamment un anticorps anti-CD19, anti-CD20, anti-CD22 ou anti-CD37. La thérapie combinée comprend, de préférence, une administration d'anticorps anti-B7 et anti-CD20.

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