C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2464394
The invention relates to tumor-specific viral replication and/or expression using conditionally replicative viral vectors in which the expression of a gene product essential for viral replication is controlled by an H19 regulatory sequence. The invention provides such viral vectors, methods of making such vectors and methods of administering such vectors. The compositions and methods of the invention are useful in the treatment of cancer and hyperproliferative disorders.
La présente invention concerne une réplication et/ou expression virale à spécificité tumorale au moyen de vecteurs viraux de réplication conditionnelle faisant que l'expression d'un produit génique essentiel pour la réplication virale est commandée par une séquence régulatrice H19. L'invention concerne également de tels vecteurs viraux, des procédés d'obtention de tels vecteurs, et des procédés d'administration de ces vecteurs. Les compositions et procédés de l'invention conviennent particulièrement pour le traitement du cancer et de troubles d'hyperprolifération.
Ayesh Suhail
Hochberg Abraham
Osler Hoskin & Harcourt Llp
Yissum Research Development Company Of The Hebrew University In
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