Thrombopoietin

Details Thrombopoietin Thrombopoietin

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2178482

Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenis.

L'invention a pour objet la thrombopoïétine isolée (TPO), l'ADN isolé codant la TPO et des procédés de recombinaison ou de synthèse pour préparer et purifier la TPO. Diverses formes de TPO ont une influence sur la réplication, la différenciation ou la maturation des cellules sanguines, particulièrment des mégakaryocytes et des cellules parentes de mégakaryocytes. Par conséquent, ces composés peuvent être utilisés pour le traitement de la thrombocytopénie.

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