Modified recombinant factor viii and von willebrand factor...

Details Modified recombinant factor viii and von willebrand factor... Modified recombinant factor viii and von willebrand factor...

A - Human Necessities

61

K

A61K 38/37 (2006.01) A61K 47/48 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2704234

The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.

L'invention concerne de nouveaux procédés permettant d'augmenter la survie d'une protéine de coagulation en inhibant l'interaction avec un récepteur de clairance. L'invention concerne également des procédés de préparation de compositions qui inhibent les récepteurs de clairance des protéines de coagulation. L'invention concerne également des protéines de coagulation conjuguées, ainsi que des compositions et des formulations les contenant.

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