Drug delivery system and method of manufacturing thereof

Details Drug delivery system and method of manufacturing thereof Drug delivery system and method of manufacturing thereof

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61K 9/00 (2006.01) A61L 31/08 (2006.01) B05D 1/02 (2006.01)

Patent

CA 2638020

Medical devices implanted or otherwise used in a mammal are made less prone to trigger adverse reactions by use of gas cluster ion-beam (GCIB) surface modification adhere various drug molecules directly into or onto the surface of medical devices, and optionally building adhered drug layers upon the first adhered layer to obtain a desired drug elution profile. This is accomplished without the need for a polymer or any other binding agent to retain the drug.

L'invention porte sur des dispositifs médicaux s'administrant par implantation ou différemment à des mammifères et moins susceptibles de provoquer des réactions adverses, en modifiant la surface à l'aide d'un faisceau d'ions d'amas de gaz pour faire adhérer directement les différentes molécules de médicament sur ou dans la surface des dispositifs médicaux et facultativement créer des couches adhérentes de médicaments sur la première couche adhérente pour obtenir le profil désiré d'élution du médicament. Cela se fait sans l'utilisation de polymères ou d'autres agents de fixation pour retenir le médicament.

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