Novel heteroaromatic compounds as inhibitors of...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/04 (2006.01) A61K 31/395 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2707313

Heteroaromatic compounds of structural formula I are inhibitors of stearoyl- coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. HetAr W-X-Ar (I)

La présente invention concerne des composés hétéroaromatiques de formule structurelle I qui sont des inhibiteurs de la coenzyme stéaroyle A delta-9 désaturase (SCD). Lesdits composés de la présente invention sont utiles dans la prévention et le traitement d'états liés à une anomalie de la synthèse et du métabolisme des lipides, notamment les maladies cardiovasculaires, l'athérosclérose, l'obésité, le diabète, les maladies neurologiques, le syndrome métabolique, la résistance à l'insuline, le cancer, la stéatose hépatique, et la stéatose hépatique non-alcoolique. HetAr_W_X_Ar(I)

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