A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/08 (2006.01) A61K 39/38 (2006.01) C07K 14/33 (2006.01) C07K 16/00 (2006.01) C07K 16/02 (2006.01) C07K 16/12 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2296765
The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A, type B and type E toxin proteins are provided. Methods which allow for the isolation of recombinant proteins free of significant endotoxin contamination are provided. The soluble, endotoxin-free recombinant proteins are used as immunogens for the production of vaccines and antitoxins. These vaccines and antitoxins are useful in the treatment of humans and other animals at risk of intoxication with clostridial toxin.
La présente invention concerne des protéines recombinées dérivées des toxines du bacille Clostridium botilinum. En particulier, l'invention décrit les protéines recombinées de la toxine du Clostridium botilinum des types A, B et E. Des procédés permettant l'isolement de protéines recombinées exemptes de contamination endotoxinique sont décrits. Les protéines recombinées solubles et exemptes d'endotoxine sont utilisées comme agents immunogènes dans la production de vaccins et d'antitoxines. Lesdits vaccins et antitoxines sont utiles dans le traitement des humains et d'autres espèces animales présentant un risque d'intoxication par la toxine clostridiale.
Thalley Bruce S.
Williams James A.
Allergan Inc.
Allergan Botox Limited
Ophidian Pharmaceuticals Inc.
Smart & Biggar
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