A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2244894
The present application discloses a finely divided, dry powdered pharmaceutical composition which is specially adapted to be administered as an insufflate which includes the following ingredients: (a) a pharmacologically effective amount of sICAM-1; (b) an amount of carboxymethyl cellulose which is effective to retain sICAM-1 on the intranasal membranes; (c) an amount of a bulking agent which is effective to provide a bulking effect without exerting a significant effect on the retention of the sICAM-1 on the nasal passages.
Cette invention concerne une composition pharmaceutique poudreuse, sèche et finement divisée, laquelle peut notamment être administrée par insufflation. Cette composition comprend les ingrédients suivants: (a) une quantité suffisante de sICAM-1 pour être efficace sur le plan pharmacologique; (b) une quantité de cellulose de carboxyméthyle suffisante pour retenir le sICAM-1 sur les membranes intranasales; et (c) une quantité suffisante d'un agent diluant qui permette d'obtenir un effet diluant sans pour autant avoir d'effet important sur la rétention du sICAM-1 dans les voies nasales.
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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