A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2496607
The present invention relates to IL-13 vaccines and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. The vaccines of the present invention comprise an IL-13 immunogen and an adjuvant composition which is a combination of a saponin and an immunostimulatory oligonucleotide comprising at least one unmethylated dinucleotide. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for their production.
La présente invention se rapporte à des vaccins IL-13 ainsi qu'à leur utilisation pour le traitement de maladies qui peuvent être traitées par neutralisation de l'IL-13, du type broncho-pneumopathie chronique obstructive (COPD), asthme et troubles atopiques tels que le rhume des foins, les allergies de contact et les dermatites atopiques. Les vaccins de la présente invention comportent un immunogène reconnaissant IL-13 et une composition d'adjuvants qui est une combinaison d'une saponine et d'un oligonucléotide immunostimulant comprenant au moins un dinucléotide non méthylé. L'invention se rapporte en outre à des compositions pharmaceutiques comportant ces immunogènes ainsi qu'à leur utilisation en médecine, et à des procédés de production de ces compositions.
Ashman Claire
Ellis Jonathan Henry
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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