Process for production of camptothecin derivative

Details Process for production of camptothecin derivative Process for production of camptothecin derivative

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) C07B 53/00 (2006.01)

Patent

CA 2649676

Disclosed is a process for production of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin from a camptothecin composition containing 18,19-dehydrocamptothecin without producing any vinyl form of the compound. The process is characterized by catalytically reducing at least one compound selected from a compound (1) and others in the process of producing a compound (5) from a composition containing the compound (1).

La présente invention concerne un procédé de production de la 7-éthyl-10-[4-(1-pipéridino)-1-pipéridino]-carbonyloxycamptothécine à partir d'une composition de camptothécine contenant la 18,19-déshydrocamptothécine sans produire de forme vinyle du composé. Le procédé est caractérisé par la réduction catalytique d'au moins un composé choisi parmi un composé (1) et d'autres dans le procédé de production d'un composé (5) à partir d'une composition contenant le composé (1).

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