A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/29 (2006.01)
Patent
CA 2617362
Inclusion of fatty adjuvants in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant involves purification of the antigen substantially in the absence of surfactant. Where surfactants cannot be avoided, the following are combined: (i) an antigen component that includes a surfactant and (ii) a fatty adjuvant component, to give a composition in which the weight ratio of said fatty adjuvant to said surfactant is less than 1000:1.
L'inclusion d'adjuvants huileux dans des compositions vaccinales peut ne pas convenir à certains composants antigènes, notamment pour des antigènes comprenant un composant tensioactifs. L'invention propose donc un procédé permettant l'élaboration d'une composition immunogène comprenant un antigène et un adjuvant gras avec purification de l'antigène sensiblement en l'absence de tout tensioactif. Lorsque le recours aux tensioactifs est inévitable, on combine (i) un composant antigène incluant un tensioactif et (ii) un adjuvant gras de façon à obtenir une composition dans le rapport massique entre l'adjuvant gras et le tensioactif est inférieur à 1000:1.
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics S.r.l.
LandOfFree
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