C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 39/112 (2006.01) C07K 14/25 (2006.01)
Patent
CA 2576124
Bacteria belonging to the Shigella genus, mutated to inactivate the function of at least one of the gene products responsible for the metabolism and/or recycling of the peptidoglycans of the cellular wall, for immunogenic use, especially mutated at S1tY, M1tA, MltB, ampG, amiA, MppA genes, and immunogenic compositions comprising them.
Cette invention concerne d'une part des bactéries appartenant au genre Shigella qui sont mutées afin qu'elles désactivent la fonction d'au moins un des produits géniques responsables du métabolisme et/ou du recyclage des peptidoglycanes de la paroi cellulaire en vue d'une utilisation immunogène, lesquelles bactéries sont spécifiquement mutées au niveau des gènes SltY, MltA, MltB, ampG, amiA, MppA, et d'autre part des compositions immunogènes les contenant.
Bernardini Maria Lina
Sansonetti J. Philippe
Dennison Associates
Inserm
Institut Pasteur
Universita Degli Studi Di Roma "la Sapienza"
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