Non-invasive gene targeting to the brain

Details Non-invasive gene targeting to the brain Non-invasive gene targeting to the brain

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2403501

Liposomes containing therapeutic genes are conjugated to multiple blood-brain barrier and brain cell membrane targeting agents to provide transport of the encapsulated gene across the blood-brain barrier and brain cell membrane. Once across the blood-brain barrier and brain cell membrane, the encapsulated gene expresses the encoded therapeutic agent within the brain to provide treatment and diagnosis of disease.

Dans le cadre de cette invention, on associe des liposomes contenant des gènes thérapeutiques à plusieurs barrières hémato-encéphaliques ainsi qu'à des agents de ciblage de membrane de cellule cérébrale et ce, afin d'assurer le transport du gène encapsulé à travers la barrière hémato-encéphalique et la membrane de cellule cérébrale. Une fois la barrière hémato-encéphalique et la membrane de cellule cérébrale traversées, le gène encapsulé exprime l'agent thérapeutique dans le cerveau afin de diagnostiquer une maladie et de la traiter.

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