A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/724 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2504663
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and /or the transplantation of blood or cells. Particular second active agents are capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use methods of the invention are also disclosed.
L'invention porte sur des méthodes de traitement, prévention et/ou gestion de syndromes myéloprolifératifs, comportant spécifiquement l'administration d'un composé immunomodulatoire ou de des sels, solvates, hydrates, stéréoisomères, clathrates, ou prodrogues, pharmacocompatibles, seuls ou associés à un deuxième agent actif et/ou à la transplantation de sang ou de cellules, certains desdits deuxièmes agents pouvant supprimer la surproduction de cellules hématopoïétiques souches ou améliorer un ou plusieurs des symptômes des syndromes myéloprolifératifs. L'invention porte également sur des préparations pharmaceutiques, des formes posologiques monolithiques, et des trousses de mise en oeuvre des méthodes de l'invention.
Celgene Corporation
Smart & Biggar
LandOfFree
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