Recombinant dna-derived cholera toxin subunit analogs

Details Recombinant dna-derived cholera toxin subunit analogs Recombinant dna-derived cholera toxin subunit analogs

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/106 (2006.01) C07K 14/28 (2006.01) C12N 1/20 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2102105

2102105 9219265 PCTABS00017 The development of subunits and subunit analogs of the cholera exotoxin by recombinant DNA techniques provides vaccine products that can retain their biological activity and immunogenicity, and can confer protection against disease challenge. Genetically-enginneered modifications of the subunits result in products that retain immunogenicity, yet are reduced in, or are essentially free of, enzymatic activity associated with toxin reactogenicity.

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