C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) A61K 38/44 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2674908
The invention relates to a multiple-specificity demethylase complex comprising a Jumonji C (JMJC) domain-containing enzyme, a process of its preparation and its use. It is the object of the present invention to provide enzymes having histone demethylating activity, particularly having broad-specifity demethylating activity and, more particularly, having tridemethylating activity. Furthermore, it is an object of the present invention to provide enzymes having demethylating activity, more particularly having tri-demethylating activity and targeting specific genes, for example the androgen receptor (AR). Moreover, it is an object of the present invention to provide a process of obtaining and isolating such enzymes. A further object of the present invention is to demonstrate such enzyme proteins for use in the medical field, particularly in the inhibition of prostate cancer, for screening purposes and for preventing the expression of AR, progesterone receptor and glucocortycoid receptor target genes by RNAi mediated knockdown of JMJD2C activity.
L'invention concerne un complexe de déméthylase à spécificité multiple qui comprend une enzyme contenant un domaine Jumonji C (JMJC), un procédé permettant sa préparation et son utilisation.
Metzger Eric
Schuele Roland
Wissmann Melanie
Fasken Martineau Dumoulin Llp
Universitaetsklinikum Freiburg
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