Surface enhanced raman spectroscopy (sers)-active composite...

G - Physics – 01 – N

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G01N 21/65 (2006.01) B82B 1/00 (2006.01) B82B 3/00 (2006.01)

Patent

CA 2536266

Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface- enhanced Raman spectroscopic active composite nanostructure. The surface- enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof. The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface- enhanced Raman spectroscopic signature.

L'invention concerne des nanoparticules, leurs procédés de préparation, et des procédés pour détecter une molécule cible au moyen de modes de réalisation de la nanoparticule. Dans un de ces modes de réalisation, la nanoparticule comprend une nanostructure composite, active, à spectrométrie laser de l'effet Raman exalté de surface. Ladite nanostructure comprend un noyau, au moins une molécule reporteur, et un matériau d'encapsulation. La molécule reporteur est liée au noyau. La molécule reporteur est sélectionnée à partir d'un colorant isocyanate, d'un colorant organique multisulfuré, d'un colorant organique multihétérosulfuré, d'un colorant de benzotriazole, et de leurs combinaisons. Le matériau d'encapsulation est disposé sur le noyau et la molécule reporteur. Après l'encapsulation au moyen du matériau d'encapsulation, la molécule reporteur présente un signature à spectrométrie laser de l'effet Raman exalté de surface mesurable.

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