Therapeutic sirna molecules for reducing vegfr1 expression...

Details Therapeutic sirna molecules for reducing vegfr1 expression... Therapeutic sirna molecules for reducing vegfr1 expression...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2702039

The invention relates to nucleic acid molecule compositions for use in modulating the expression and activity of VEGF pathway genes and decreasing unwanted neovascularization, including tumor angiogenesis, by RNA interference and methods and compositions comprising the nucleic acid molecules.

La présente invention concerne des compositions de molécules d'acide nucléique destinées à être utilisées dans la modulation de l'expression et de l'activité des gènes de la voie VEGF et dans la diminution de la néovascularisation indésirable, incluant l'angiogenèse tumorale, par interférence ARN. L'invention concerne également des procédés et des compositions comprenant lesdites molécules d'acide nucléique.

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