A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/702 (2006.01) A61K 31/7028 (2006.01) A61K 31/715 (2006.01) A61K 31/739 (2006.01) A61P 5/48 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2569891
The present invention relates generally to a method of modulating integrin- mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating ab integrin-mediated cellular activity by modulating GPI-related signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate integrin-mediated cellular activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject integrin dependent signalling mechanism.
La présente invention concerne d'une façon générale un procédé permettant de moduler l'activité cellulaire médiée par l'intégrine et des agents convenant à cet effet. L'invention concerne plus particulièrement un procédé permettant de moduler l'activité cellulaire médiée par l'intégrine .alpha..beta. par une modulation de la signalisation en relation avec le glycosyl-phosphati-dylinositol. L'invention concerne également, notamment le traitement et/ou la prophylaxie d'états caractérisés par une activité cellulaire médiée par l'intégrine, non souhaitée ou autrement inappropriée. L'invention concerne enfin des procédés permettant d'identifier et/ou de concevoir des agents capables de moduler chez un sujet le mécanisme de signalisation dépendant de l'intégrine.
Schofield Louis
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Walter And Eliza Hall Institute Of Medical Research
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