C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) C07D 211/68 (2006.01) C07D 401/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2403600
Compounds of general formula (I), where R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1- C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
L'invention concerne des composés de formule générale (I), dans laquelle R?1¿ peut être phényle, pyridinyle, thiényle, furanyle, imidazolyle, et triazolyle; chaque chaîne phényle R?1¿ et chaque chaîne hétéroaromatique R?1 ¿peut éventuellement et indépendamment être substituée par 1, 2 ou 3 substituants qui peuvent être alkyle C¿1?-C¿6? à chaîne droite ou ramifiée, NO¿2?, CF¿3?, C¿1?-C¿6? alcoxy, chloro, fluoro, bromo, et iodo. Les substitutions sur les deux chaînes susmentionnées peuvent intervenir en une position quelconque. L'invention englobe les sels pharmaceutiquement acceptables des composés considérés et les compositions pharmaceutiques qui contiennent lesdits composés, ainsi que leur utilisation en thérapie, notamment pour le traitement de la douleur.
Brown William
Walpole Christopher
Wei Zhongyong
Astrazeneca Ab
Fetherstonhaugh & Co.
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