Pharmaceutically active tetrahydro-pyrrolo[1,2-b]isothiazole...

Details Pharmaceutically active tetrahydro-pyrrolo[1,2-b]isothiazole... Pharmaceutically active tetrahydro-pyrrolo[1,2-b]isothiazole...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2624493

3a,4,5,6-Tetrahydro-pyrrolo1 ,2-b]-isothiazoles wherein the sulphur is in the form of a dioxide and their use for the treatment or prevention of disorders mediated by interactions of LFA-1 with its ligands involved in cell adhesion, migration and activation.

La présente invention a pour objet des 3a,4,5,6-tétrahydropyrrolo[1,2-b]isothiazoles où le soufre est sous forme de dioxyde et leur emploi dans le traitement prophylactique ou thérapeutique de troubles faisant intervenir les interactions de LFA-1 avec ses ligands impliqués dans l'adhésion, la migration et l'activation cellulaire.

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