Method for preparing solid phase conjugate vaccines

Details Method for preparing solid phase conjugate vaccines Method for preparing solid phase conjugate vaccines

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/09 (2006.01) A61K 39/095 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) C07K 16/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2348063

A method of preparing conjugate vaccines by adsorbing a protein to a solid phase adjuvant, and covalently linking a carbohydrate to the adsorbed protein. Alternatively, the carbohydrate is first adsorbed to the solid phase adjuvant, then the protein is covalently linked to the carbohydrate. The carbohydrate may be chemically activated. Unconjugated protein may be present.

Cette invention concerne un procédé de préparation de vaccins conjugués par adsorption d'une protéine sur un adjuvant en phase solide, puis par liaison d'un glucide à la protéine adsorbée. En variante, le glucide est d'abord adsorbé sur l'adjuvant en phase solide, puis la protéine est liée à ce glucide par covalence. Le glucide peut être activé chimiquement. Une protéine non conjuguée peut être présente.

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