C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/78 (2006.01) A61K 31/155 (2006.01) A61K 31/16 (2006.01) A61K 31/714 (2006.01) A61P 25/28 (2006.01) C07K 7/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2758829
A method of inhibiting Peptidyl Argininedeiminase (PAD) in a mammal is provided wherein said method comprises the step of administering 2-haloacetamidine to a mammal. The method is useful to treat a demyelinating disease in mammals such as multiple sclerosis, as well as other diseases in which hyper- citrullination is a factor. Pharmaceutical compositions useful to treat said disease are also provided, as well as a method of screening for PAD inhibitors.
L'invention porte sur un procédé d'inhibition de la peptidyl-arginine désiminase (PAD) chez un mammifère, ledit procédé comprenant l'étape consistant à administrer de la 2-haloacétamidine à un mammifère. Le procédé est utile pour traiter une maladie de démyélinisation chez des mammifères telle que la sclérose en plaques, ainsi que d'autres maladies dans lesquelles l'hypercitrullination est un facteur. L'invention porte également sur des compositions pharmaceutiques utiles pour traiter ladite maladie, ainsi que sur un procédé de criblage d'inhibiteurs de PAD.
Mastronardi Fabrizio
Moscarello Mario A.
Wood Denise
Gowling & Henderson
Synorg Chemicals Inc.
The Hospital For Sick Children
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