Nitric oxide inhibits rhinovirus infection

Details Nitric oxide inhibits rhinovirus infection Nitric oxide inhibits rhinovirus infection

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/00 (2006.01) A61K 31/15 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2303430

Nitric oxide generating compounds or compounds which induce in situ synthesis of nitric oxide can be used to inhibit rhinovirus infection. Nitric oxide has the ability to inhibit both viral replication as well as the synthesis of cytokines, in particular the proinflammatory cytokines. Thus the symptoms of rhinovirus infections can be ameliorated by treatments to increase nitric oxide in the respiratory tract.

On peut utiliser des composés générant du monoxyde d'azote ou des composés qui induisent in situ la synthèse du monoxyde d'azote, pour inhiber l'infection par rhinovirus. Le monoxyde d'azote a la capacité d'inhiber à la fois la réplication virale et la synthèse des cytokines, notamment les cytokines proinflammatoires. Ainsi, les symptômes d'infections par rhinovirus peuvent être atténués par des traitements visant à augmenter le taux de monoxyde d'azote dans l'appareil respiratoire.

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