Endoderm, cardiac and neural inducing factors

Details Endoderm, cardiac and neural inducing factors Endoderm, cardiac and neural inducing factors

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2258789

Novel proteins have been designated "cerberus" and "frzb-1", respectively. Cerebus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is termed PAPC which promotes the formation of dorsal mesoderm and somites in the embryo.

De nouvelles protéines ont été baptisées "cerberus" et "frzb-1", respectivement Cerberus est exprimée comme un peptide secrété pendant l'embryogenèse de l'embryon du xénope, et exprimée spécifiquement dans la principale région d'organisation. La nouvelle molécule a une activité inductrice des tissus endodermiques, cardiaques et neuronaux qui se révèle utile dans des applications thérapeutiques, diagnostiques et cliniques nécessitant une régénération, une différenciation ou une réparation desdits tissus ou d'autres tissus. Frzb-1 est un antagoniste soluble des facteurs de croissance de la famille Wnt qui agit en se liant aux facteurs de croissance Wnt dans l'espace extracellulaire. Une troisième nouvelle protéine, appelée PAPC, provoque la formation du mésoderme dorsal et de métamères dans l'embryon.

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