Synthesis of resorcylic acid lactones useful as therapeutic...

Details Synthesis of resorcylic acid lactones useful as therapeutic... Synthesis of resorcylic acid lactones useful as therapeutic...

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61K 31/4025 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 35/00 (2006.01) C07D 225/06 (2006.01)

Patent

CA 2755876

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

L'invention concerne des composés macrocycliques de formules I, I', II, II', III, III', IV, et V, qui sont des analogues de lactones d'acide résorcylique de pochonine, des compositions pharmaceutiques comprenant les composés, et des procédés et utilisations comprenant les composés pour le traitement de maladies provoquées par des kinases et une protéine de choc thermique 90 HSP90.

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