Pyrazinones, compositions containing such compounds

Details Pyrazinones, compositions containing such compounds Pyrazinones, compositions containing such compounds

C - Chemistry, Metallurgy

07

D

C07D 241/20 (2006.01) A61K 31/497 (2006.01) A61P 25/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2378834

Compounds represented by formula (I) as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat caspase-3 mediated diseases and conditions.

Cette invention se rapporte à des composés représentés par la formule (I), ainsi qu'à des sels, esters, N-oxydes et hydrates de ces composés, acceptables sur le plan pharmaceutique. Des compositions pharmaceutiques et des procédés d'utilisation sont également décrits. Ces composés sont actifs contre l'enzyme caspase-3 et ils sont par conséquent utiles pour traiter les maladies et les états induits par la caspase-3.

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