C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2370617
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-8, and polypeptide variants thereof that stimulate dephosphorylation of DSP-8 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-8 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
La présente invention concerne des compositions et des méthodes destinées au traitement de troubles liés à la prolifération, à la différentiation et à la survie cellulaire. Elle concerne plus particulièrement la phosphatase double spécificité DSP-8, des variants de polypeptides de celle-ci qui stimulent la déphosphorylation des substrats DSP-8. On peut utiliser ces polypeptides, par exemple, pour identifier des anticorps et d'autres agents qui inhibent l'activité DSP-8. On peut utiliser ces polypeptides et ces agents pour moduler la prolifération, la différentiation et la survie cellulaire.
Luche Ralf M.
Wei Bo
Ceptyr Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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